Biostatistics in Action Seminar Series: Tips for Clinical Researchers
"Limb-Leaf Designs for Adaptive Exploration of the Dose-Response Curve"
Dr. Cheng will propose a two-stage strategy, called the Limb-Leaf method, to explore the dose-response curve using dose promotion and addition in the context of adaptive seamless Phase II/III trials. Strong control of the overall type 1 familywise error rate of the proposed method is enforced by the closed testing principle. The design constants are determined to minimize the risk-adjusted expected total sample size while maintaining a target power. In the case of a non-monotonic dose response curve where more doses are required to adequately explore the curve, substantial savings in sample size are achieved compared with a traditional strategy which offers only selection and promotion from among initial first stage doses.
Please RSVP: https://www.eventbrite.com/e/limb-leaf-designs-for-adaptive-exploration-of-the-dose-response-curve-tickets-61174847616
Livestream available at: https://echo360.org/section/925d2164-12a2-4c83-834c-d83fd214a58e/public
Questions? Contact Cody Chiuzan –
[email protected]
